Cook the spaghetti in a large pot of boiling salted water until al dente, then drain and set aside.
Mix ground beef, bread crumbs, egg, salt, and pepper in a bowl until well combined. Shape the mixture into small, round meatballs roughly 1 inch in diameter.
Heat olive oil in a skillet over medium heat. Add the meatballs and cook until browned on all sides and cooked through, about 10 minutes. Transfer to a baking sheet and let cool slightly.
Mix red food coloring into the tomato sauce to create a bloodshot, red appearance.
Add the cooked meatballs back into the sauce and simmer for 10 minutes, allowing the flavors to meld and the sauce to thicken slightly.
Serve the spaghetti on plates, then top each portion with several meatballs arranged on the pasta.
Decorate each meatball with a black sesame seed in the center to create the pupil, pressing them gently into the surface for a realistic eyeball effect.
Use additional red sauce to drip around the meatballs, enhancing the bloody, horror effect and making them look more sinister.
Garnish with extra sauce or decorative edible details as desired to enhance the spooky appearance.
Enjoy your creepy, fun eyeball pasta with friends and family, perfect for a Halloween night filled with playful scares!